Impaired Whole-Blood Polymorphonuclear Leukocyte Migration as a Possible Predictive Marker for Infections in Preterm Premature Rupture of Membranes

摘要

Objectives: Steroids, used in pretermpremature rupture of membranes (pPROM), to reduce the risk of morbidityand mortality of the preterm neonate, impair the maternal polymorphonuclear leukocyte (PMN)-based immunesystem. In spite of combination with antibiotics, prenatal and postnatal bacterial infections of mother and child arefrequent. This pilot study focuses on the influence of steroids in pPROM on maternal PMN functional capacity andsubsequent infections.